In this study, we investigated the neurochemical alterations in mouse hippocampus using in vivo proton magnetic resonance spectroscopy. We also examine the effect of high-fat diet on the levels of abdominal fat, plasma leptin, and corticosterone. The decrease in mIns concentration seen in HF diet mice without corresponding Gln-Glu alternation may reflect changes in glial function. In addition, the observed total choline levels indicate attenuated membrane turnover in HF diet mice. We therefore suggest that diets rich in saturated fats induce a stress-related response through metabolic disturbance and HPA axis dysfunction, which may indicate a relationship between obesity and depression.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords