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Abstract #5636

Reliability of in vivo Glx measurements from GABA-edited MRS at 3T

Elodie Boudes1,2, Rachelle S Loo1,2, Kari AL Parsons1,2, Gareth J Barker3, David Lythgoe3, Richard AE Edden4,5, R Marc Lebel6, Martin P Wilson7, and Ashley D Harris1,2

1Radiology, University of Calgary, Calgary, AB, Canada, 2CAIR Program, Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, 3Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 4Radiology, The Johns Hopkins School of Medicine, 5F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 6General Electric Healthcare, 7School of Psychology, University of Birmingham

Mixed glutamate/glutamine (GLX) signal contributes to spectra acquired for GABA editing, both as a co-edited peak in the difference spectrum and in the OFF subspectrum. GLX results are often included in GABA studies, but the reliability of these metrics has received little attention. In this study, we examine the relationship between GLX measures, using a short-TE PRESS as a “gold standard”, and comparing GLX measured from the co-edited peak and the OFF subspectrum from typical GABA+ and macromolecule-suppressed GABA acquisitions.

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