Abstract #5636

Reliability of in vivo Glx measurements from GABA-edited MRS at 3T

Elodie Boudes^1,2, Rachelle S Loo^1,2, Kari AL Parsons^1,2, Gareth J Barker³, David Lythgoe³, Richard AE Edden^4,5, R Marc Lebel⁶, Martin P Wilson⁷, and Ashley D Harris^1,2

¹Radiology, University of Calgary, Calgary, AB, Canada, ²CAIR Program, Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, ³Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, ⁴Radiology, The Johns Hopkins School of Medicine, ⁵F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, ⁶General Electric Healthcare, ⁷School of Psychology, University of Birmingham

Mixed glutamate/glutamine (GLX) signal contributes to spectra acquired for GABA editing, both as a co-edited peak in the difference spectrum and in the OFF subspectrum. GLX results are often included in GABA studies, but the reliability of these metrics has received little attention. In this study, we examine the relationship between GLX measures, using a short-TE PRESS as a “gold standard”, and comparing GLX measured from the co-edited peak and the OFF subspectrum from typical GABA+ and macromolecule-suppressed GABA acquisitions.

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