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Abstract #5637

Prognostic utility of cervicovaginal fluid acetate-glutamate ratio for risk of preterm delivery within two weeks of presentation with symptoms of threatened preterm labour

Emmanuel Amabebe1, Steven Reynolds2, Victoria Stern1, Graham Stafford3, Martyn Paley2, and Dilly Anumba1

1Academic unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffiled, United Kingdom, 2Academic unit of Radiology, University of Sheffield, Sheffiled, United Kingdom, 3School of Clinical Dentistry, University of Sheffield, Sheffiled, United Kingdom

Accurate identification of pregnant women with symptoms of preterm labor (PTL) most likely to deliver prematurely soon after presentation/assessment is crucial for prompt clinical decision making and allocation of scarce resources by minimizing unnecessary hospitalizations and treatments, as well as by triaging patients to the centers with optimal care facilities. We determined the predictive capacity of cervicovaginal fluid (CVF) acetate/glutamate ratio in pregnant women presenting with symptoms of threatened PTL using 1H-NMR. The ratio of CVF acetate to glutamate demonstrated better prediction of delivery within 2 weeks of symptomatic presentation, compared to either acetate or glutamate alone.

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