Abstract #5641

Cerebral Metabolite Changes and Cognitive Clinical Correlates in Perinatally HIV-infected Young Adults

Manoj K Sarma¹, Margaret A Keller², Tamara Welikson³, Sathya Arumugam ¹, David E Michalik⁴, Irwin Walot⁵, Karin Nielsen-Saines⁶, Jaime Deville⁶, Andrea Kovacs⁷, Eva Operskalski⁷, Joseph Ventura⁸, and M. Albert Thomas¹

¹Radiological Sciences, UCLA School of Medicine, Los Angeles, CA, United States, ²Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States, ³Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, Los Angeles, CA, United States, ⁴Infectious disease-Pediatrics, Miller Children's Hospital, Long Beach, CA, United States, ⁵Radiology, Harbor-UCLA Medical Center, Torrance, CA, United States, ⁶Pediatrics, UCLA School of Medicine, Los Angeles, CA, United States, ⁷Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, United States, ⁸Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, United States

A recently implemented 5D echo-planar J-resolved spectroscopic sequence using 8x acceleration and compressed sensing reconstruction was evaluated in 7 perinatally infected and 8 healthy youths. Selected metabolite ratios with respect to Cr were detected bilaterally in the basal ganglia, anterior insular cortex, posterior insular cortex, frontal white and occipital/frontal gray regions of the two groups. Statistically significant differences were found between metabolite ratios (/Cr) of HIV-infected youing adults and healthy control subjects in the occipital gray N-acetylaspartate, right basal ganglia glutamine/glutamate, left anterior insular cortex choline, and left posterior insular cortex. Also, our pilot findings suggest a possible difference in energy metabolism between perinatally HIV-infected young adults and controls without HIV. The metabolite ratios correlated with neuropsychological test scores showing cognitive impairment as result of HIV-infection and/or long term ART.

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