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Abstract #5642

In vivo measurement of metabolic changes associated with chick embryo development using 1H-NMR spectroscopy at 14.1 Tesla

Antoine Cherix1, Brodier Laurent2,3, Jean-Marc Matter2,3, and Rolf Gruetter1,4,5

1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Department of Biochemistry, University of Geneva, Geneva, Switzerland, 3Department of molecular biology, University of Geneva, Geneva, Switzerland, 4Department of Radiology, University of Geneva, Geneva, Switzerland, 5Department of Radiology, University of Lausanne, Lausanne, Switzerland

1H-MRS was used to study the metabolic changes associated with development of the neural tissue in vivo longitudinally. Different tissues (yolk, eye and vitreous body) of developing chickembryos were scanned at three different stages (E3, E6 and E8) for metabolic quantification. As expected, results indicate that a critical juncture appears between stages E3 and E6 in terms of energetic status of the embryo.

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