Abstract #5649

Using broadband refocusing pulses for increased sensitivity for 2HG detection to determine glioma IDH mutation status

Sunitha B Thakur¹, Robert J Young¹, Robin Fatovic¹, Ralph Noeske², Martin Janich³, Andrei Holodny¹, and Ingo K Mellinghoff¹

¹Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²GE HealthCare, Berlin, Germany, ³GE Global Research, Munich, Germany

2-hydroxyglutarate in IDH1/2 mutated tumors is of clinical interest and can be measured in-vivo by magnetic resonance spectroscopy. Goal of this work was to compare results obtained using the standard reduced flip angle refocusing pulses with results using broadband refocusing pulses. Sensitivity improvement was observed in phantoms and demonstrated in vivo.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.