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Abstract #5649

Using broadband refocusing pulses for increased sensitivity for 2HG detection to determine glioma IDH mutation status

Sunitha B Thakur1, Robert J Young1, Robin Fatovic1, Ralph Noeske2, Martin Janich3, Andrei Holodny1, and Ingo K Mellinghoff1

1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2GE HealthCare, Berlin, Germany, 3GE Global Research, Munich, Germany

2-hydroxyglutarate in IDH1/2 mutated tumors is of clinical interest and can be measured in-vivo by magnetic resonance spectroscopy. Goal of this work was to compare results obtained using the standard reduced flip angle refocusing pulses with results using broadband refocusing pulses. Sensitivity improvement was observed in phantoms and demonstrated in vivo.

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