Abstract #5650

1H NMR based metabolomics study of serum in Parkinson’s patients

Sadhana Kumari¹, Senthil Kumaran¹, Vinay Goyal², SN Dwivedi³, Achal Srivastava², and Naranamangalam R Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

Proton metabolic profile of serum samples in 20 patients with Parkinson’s disease (PD) and 10 healthy controls (HC) was studied using 700 MHz NMR spectrometer. Data were processed using MestReNova software (version: 10.0) and integral values were evaluated. PLS-DA multivariate analysis was performed to compare the metabolic differences between PD patients and HC using MetaboAnalyst (version: 3.0) software. We found elevated levels of glucose, fatty acid, glutamine, lactate, choline, creatine and acetate in PD patients in comparison with HC (on t-test, p<0.05), indicating disturbances in lipid metabolism, fatty acid oxidation and mitochondrial damage leading to dopaminergic deficiency in Parkinson's disease.

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