Abstract #5651

NEURO 2D CORRELATED SPECTROSCOPY IDENTIFIES NEURO DEREGULATION IN SOLDIERS EXPOSED TO BLAST PRIOR TO DISCERNIBLE CHANGES BY CONVENTIONAL IMAGING

Graham J Galloway^1,2, Scott G Quadrelli^1,3,4, Aaron J Urquhart¹, Katie Trickey¹, Peter Malycha¹, Theresa Keane⁵, and Carolyn E Mountford¹

¹Translational Research Institute, Woolloongabba, Australia, ²Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ³University of Newcastle, Australia, ⁴Institute for Health and Biomedical Innovation, Brisbane, Australia, ⁵Department of Defence, Australian Government, Sydney, Australia

This pilot study reports clear deregulation in the neurochemistry of defense personnel exposed to repeated blast. The changes recorded are different to those reported for mTBI, PTSD and chronic pain. No differences between blast exposed and healthy were recorded by MRI sequences T1WI, FLAIR or SWI. In vivo neuro 2D spectroscopy recorded deregulation with PC and GPC, NAA and GABA all decreased compared to the healthy non exposed brain. We we did not observe any changes in the fucosolated glycans, which are reflective of pain, repetitive brain injury and/or cognitive deficit.

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