Abstract #5652

7T Brain MRS in HIV Infection: Effects of Cognitive Impairment

Mona A Mohamed¹, Peter B Barker¹, Richard Skolasky², and Ned C Sacktor³

¹Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, United States, ²Orthopedic, Johns Hopkins Medical Institutions, Baltimore, MD, United States, ³Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, United States

Higher magnetic field such as 7T provides increased sensitivity, better signal to noise ratio and more reliable measure of the metabolite concentrations. In this study, 7T MRS was used to measure brain metabolites in HIV+ patients in 5 brain regions. Our study showed impaired neuronal integrity across the white and gray matter as well as possible impaired astrocyte osmoregulation in patients with symptomatic cognitive impairment. In conclusion, 7T MRS brain metabolites measurement can be used as reliable biomarkers for the assessment of cognitive status in HIV+ patients.

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