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Abstract #5653

Microstructural dynamic changes in ischemic stroke in humans measured with diffusion-weighted magnetic resonance spectroscopy at 3 T

Francesca Branzoli1,2, Bélen Díaz-Fernández 3, Malgorzata Marjanska4, Edward Auerbach4, Romain Valabrègue1,2, Itamar Ronen5, Stéphane Lehéricy1,2, and Charlotte Rosso1,2,3

1Brain and Spine Institute (ICM), Center for Neuroimaging Research (CENIR), Paris, France, 2UPMC Paris 6, INSERM, U1127; CNRS, UMR 7225, Paris, France, 3Service des Urgences Cérébrovasculaires, Hòpital Pitié-Salpétrière, Paris, France, 4Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 5C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Diffusion-weighted 1H magnetic resonance spectroscopy (DW-MRS) probes the diffusion properties of metabolites, which are differentially compartmentalized in brain tissue and are thus more specific than water molecules to the intra-cellular environment. The aim of this study was to measure water and metabolite diffusion in the human brain in the acute, sub-acute and choronic stage of ischemic stroke, in order to better characterize the microstructural dynamic changes ongoing at different stages of the disease, in both infarcted and periferal regions, by disentangling neuronal, glial and extra-cellular pathological processes.

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