Abstract #5654

Enhanced detection of weak metabolites with short initial echo time 2D L-COSY

Jameen ARM¹, Karen Ribbons², Jeannette Lechner-Scott³, Kate Skehan⁴, Shiami Luchow³, M. Albert Thomas⁵, and Saadallah Ramadan⁶

¹University of Newcastle, Newcastle, Australia, ²John Hunter Hospital, Australia, ³Hunter Medical Research Institute, Australia, ⁴HMRI Imaging centre, Hunter Medical Research Institute, Australia, ⁵University of California Los Angeles, CA, United States, ⁶University of Newcastle, Australia

The detection of weak neurometabolites such as g-aminobutyric acid (GABA), glutathione (GSH), glycerophosphocholine (GPC), phosphorylethanolamine (PE) with 2D L-COSY can be challenging due to lower concentrations. Moreover, the standard initial echo time (TE_initial) of 30ms yields suboptimal SNR due to shorter T2*. In this study, we compared short TE_initial of 20ms vs 30ms to evaluate improved detection of low concentration metabolites. Our results show a significant increase in SNR with TE_initial of 20ms compared to 30ms. Short TE_initial of 20ms has increased potential in the detection of peaks from weak neurometabolites.

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