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Abstract #5654

Enhanced detection of weak metabolites with short initial echo time 2D L-COSY

Jameen ARM1, Karen Ribbons2, Jeannette Lechner-Scott3, Kate Skehan4, Shiami Luchow3, M. Albert Thomas5, and Saadallah Ramadan6

1University of Newcastle, Newcastle, Australia, 2John Hunter Hospital, Australia, 3Hunter Medical Research Institute, Australia, 4HMRI Imaging centre, Hunter Medical Research Institute, Australia, 5University of California Los Angeles, CA, United States, 6University of Newcastle, Australia

The detection of weak neurometabolites such as g-aminobutyric acid (GABA), glutathione (GSH), glycerophosphocholine (GPC), phosphorylethanolamine (PE) with 2D L-COSY can be challenging due to lower concentrations. Moreover, the standard initial echo time (TEinitial) of 30ms yields suboptimal SNR due to shorter T2*. In this study, we compared short TEinitial of 20ms vs 30ms to evaluate improved detection of low concentration metabolites. Our results show a significant increase in SNR with TEinitial of 20ms compared to 30ms. Short TEinitial of 20ms has increased potential in the detection of peaks from weak neurometabolites.

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