Abstract #5655

Investigation of long-term effect of a high-fat diet using quantitative MRI and 1H MRS for assessing body and liver fat, and muscle mass

Jong-Hee Hwang¹, In-Young Lee², Jung-Hyun Kim², and Jae Seung Kim²

¹Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research, Heinrich Heine University, Düsseldorf, Germany, ²Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea, Republic of

Repetitive and noninvasive MR examinations of fat content can provide indispensable information for longitudinal metabolic studies. It is of great interest to understand how obesity in youth affects the fat metabolism later in life. Thus we longitudinally examined mice with/without a high-fat diet [HFD] for 8 weeks from 13 to 67 weeks old using MRI and 1H MRS. As a result, visceral fat restored normalcy in 10 weeks after the termination of HFD, subcutaneous and liver fat returned to normalcy in ~ 16 - 20 weeks as compared to controls.

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