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Abstract #5656

Simultaneous Quantification of Body and Liver Fat using MRI and 1H MRS: Their Associations with Adipokines in Patients with Antipsychotics

Jong-Hee Hwang1, Jung-Hyun Kim2, Pil-Whan Park3, Jürgen Machann4, Michael Roden1, Sheen-Woo Lee5, and Jong-Hoon Kim6

1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research, Heinrich Heine University, Düsseldorf, Germany, 2Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea, Republic of, 3Department of Laboratory Medicine, Gachon University, Incheon, Korea, Republic of, 4Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany, 5Department of Radiology, Gachon University, Incheon, Korea, Republic of, 6Neuroscience Research Institute, Gachon University, Incheon, Korea, Republic of

To date, quantitative analyses of body fat content along with key adipokines have not been reported for patients treated with antipsychotics. Thus, in the groups of schizophrenia patients with antipsychotic treatment and age- and body mass index (BMI) matched healthy controls, we report abdominal and liver fat content by MRI and 1H MRS, plasma levels of leptin and adiponectin, and their associations. As a result, liver fat content was inversely correlated with adiponectin levels in age- and BMI- matched controls (r=-0.873, p=0.0004), but not in the patients. In both groups, visceral fat was inversely correlated with adiponectin, while subcutaneous fat was positively correlated with leptin levels.

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