Abstract #0002

The Effect of Model Compliance and Pulsatile Flow for In-Vitro Simulation of the Aorta

Timothy Aaron Ruesink¹, Matthew Smith^2,3, Katrina Ruedinger⁴, Christopher J François^2,3, and Alejandro Roldán-Alzate^1,2,4

¹Mechanical Engineering, University of Wisconsin, Madison, WI, United States, ²Radiology, University of Wisconsin, Madison, WI, United States, ³School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin, Madison, WI, United States

In-vitro cardiovascular simulation permits quantification of hemodynamics that cannot be assessed in-vivo. However, simulation accuracy depends on anatomical and physiological realism of in-vitro models and flow. To determine the effect of model compliance and pulsatile flow, a rigid model of an aorta was compared with a geometrically identical compliant model. Models were perfused with pulsatile flow using a positive displacement pump. Flow dynamic parameters for simulations, obtained using 4D flow MRI, showed that model compliance plays a significant role in hemodynamics during pulsatile flow. Future development of realistic in-vitro simulation, paired with in-vivo validation, will aid in surgical planning.

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