4D flow MRI supports the development of novel energetic biomarkers in hypertrophic cardiomyopathy (HCM) – a disease marked by dynamic left ventricular outflow tract obstruction with mitral regurgitation (MR). We compared kinetic energy and velocity metrics between obstructive and non-obstructive HCM subtypes to determine where in the left heart high kinetic energy and flows were generated. Left atrium showed significantly higher systolic kinetic energy and velocities throughout ventricular systole due to MR. Including these energetic parameters may be useful to detect significant MR that is underestimated by echo, identify patients at higher risk of atrial fibrillation, and inform treatment options.
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