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Abstract #0035

Simultaneous Proton Density Fat Fraction Imaging and Water T1-Mapping with Low B1+ Sensitivity (PDFF-T1)

Richard B Thompson1, Kelvin Chow2, and Justin Grenier1

1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States

Quantitative multi-parametric MR imaging is an important component of diagnosis and objective staging of diffuse liver disease, reducing the need for biopsy. The goal of the current study was to validate a new simultaneous proton density fat fraction and water T1-mapping approach (PDFF-T1) with low B1+ sensitivity in a short, patient-friendly breath-hold acquisition. It is shown (simulations, phantoms, in-vivo) that a time-varying flip angle excitation scheme leads to improved accuracy of PDFF and that fat-water separation enables water-specific T1 mapping, all in a single patient-friendly breath-hold, with low sensitivity to inhomogeneity in the transmitted radiofrequency (B1+) field.

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