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Abstract #0037

Differential Sensitivity of Various Microstructural Metrics to Training-Induced White Matter Dynamics

Debbie Anaby1, Benjamin Tendler2, Chantal M.W. Tax1, Greg D Parker1, Yaniv Assaf3,4, and Derek K Jones1

1Cardiff University Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

Previous in-vivo MRI studies on training-induced WM microstructural dynamics were mostly based on DTI measurements showing changes in FA. The non-specificity of FA as a WM marker stimulated us to obtain a more specific characterization of WM microstructural changes. Using multi-parametric MR with the ‘Tractometry’ approach we show significant changes in the fornix post a navigation working memory task. Critically, we report here for the first time significant microstructural changes with susceptibility, shown in vast areas of the fornix. Fr, MD, RD and λ1 also show significant changes but in limited areas of the fornix.

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