Abstract #0037

Differential Sensitivity of Various Microstructural Metrics to Training-Induced White Matter Dynamics

Debbie Anaby¹, Benjamin Tendler², Chantal M.W. Tax¹, Greg D Parker¹, Yaniv Assaf^3,4, and Derek K Jones¹

¹Cardiff University Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ²Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ³Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, ⁴Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

Previous in-vivo MRI studies on training-induced WM microstructural dynamics were mostly based on DTI measurements showing changes in FA. The non-specificity of FA as a WM marker stimulated us to obtain a more specific characterization of WM microstructural changes. Using multi-parametric MR with the ‘Tractometry’ approach we show significant changes in the fornix post a navigation working memory task. Critically, we report here for the first time significant microstructural changes with susceptibility, shown in vast areas of the fornix. Fr, MD, RD and λ1 also show significant changes but in limited areas of the fornix.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.