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Abstract #0064

Novel Tumor-Selective Dual-Contrast 3D MRI Toward Zero False-Positiveness in Brain Metastases: A Feasibility Study

Hoonjae Lee1,2, Seong-gi Kim1, and Jaeseok Park3

1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Republic of Korea, 2Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea, 3Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea

The purpose of this work is to develop a novel, tumor-selective dual-contrast 3D MRI technique that can clearly differentiate small brain metastases from contrast-enhanced vessels while potentially eliminating false-positiveness in the corresponding diagnosis. After injecting contrast agents, the proposed pulse sequence employs a pair of mixed encodings in each TR, yielding highly tumor-selective, blood-suppressed images from the latter to increase the sensitivity of metastases detection while producing blood-enhanced signals from the former to evaluate the false-positiveness of the detected metastases. It is expected that the proposed method enhances detection sensitivity to brain metastases while substantially reducing false-positiveness.

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