Abstract #0067

Measuring human placental blood flow with multi-delay 3D GRASE pseudo-continuous arterial spin labeling at 3 Tesla

Xingfeng Shao¹, Dapeng Liu², Thomas Martin², Teresa Chanlaw³, Sherin U. Devaskar³, Carla Janzen⁴, Aisling M. Murphy⁴, Daniel Margolis², Kyunghyun Sung², and Danny J.J. Wang¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ³Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁴Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

Placenta influences the health of both a woman and her fetus during pregnancy. Maternal blood supply to placenta can be measured non-invasively using arterial spin labeling (ASL). The purpose of this study is to present a multi-delay pseudo-continuous arterial spin labeling (pCASL) combined with a fast 3D inner-volume gradient- and spin-echo (GRASE) imaging technique to simultaneously measure placental blood flow (PBF) and arterial transit time (ATT), and to study PBF and ATT evolution with gestational age during the second trimester. The PBF values were compared with uterine arterial Doppler ultrasound to assess its potential clinical utility.

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