Abstract #0066

Arterial-Spin-Labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: a four-year longitudinal study

Jill B De Vis¹, Shin-Lei Peng², Xi Chen³, Yang Li¹, Peiying Liu¹, Sandeepa Sur¹, Karen M Rodrigue³, Denise C Park³, and Hanzhang Lu¹

¹MR Research, Johns Hopkins University, Baltimore, MD, United States, ²Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ³Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas, Dallas, TX, United States

Identification of biomarkers that can predict cognitive decline is of utmost importance for advance in dementia pharmacotherapy. In this study, cerebral blood flow (CBF) is investigated as a predictor for cognitive decline in a healthy aging population. We found CBF in the frontal lobe to be most predictive for cognitive decline, specifically for episodic memory and in the older population. This suggest that CBF can be used as a biomarker to identify subjects susceptible to cognitive decline, to identify suitable cohorts for clinical trials, and to monitor the effects of pharmacotherapy.

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