Accurate differentiation between intrahepatic cholangiocarcinoma (IHCC) and hepatocellular carcinoma (HCC) is essential for adequate treatment planning. In the present study, non-contrast volumetric ADC histogram analysis was employed to differentiate IHCC (n=33) and HCC (n=98). The results suggested that except the kurtosis and skewness, all the volumetric ADC histogram parameters, were helpful in distinguishing IHCC from HCC. Among all the parameters, 75th percentile ADC was most helpful to distinguish the two diseases. This non-contrast method provides useful information in differentiating IHCC from HCC, it benefits patients who are contraindicate to contrast agents.