The study of the spatial distribution of multiple sclerosis (MS) lesions in the cervical spinal cord provides a means to further understand the disease pathophysiology. In this study we involve 358 patients across 7 sites, where cervical lesions were manually segmented. Using Spinal Cord Toolbox, lesion segmentations were registered to a common-space template and voxel-based lesion probability maps (LPMs) were computed across the patient population to assess lesion topography. Results revealed a predominance of lesions in the upper cord (C1-C3) and dorsal column, which confirms prior histopathology work and encourages further study of associations between cervical spine lesion volume and distribution with clinical status.
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