Abstract #0084

Thalamic lesions, thalamic volume and cognitive deficit in secondary progressive MS

Floriana De Angelis¹, Jonathan Stutters¹, Arman Eshaghi¹, Ferran Prados^1,2, Domenico Plantone¹, Anisha Doshi¹, Nevin John¹, David MacManus¹, Sebastien Ourselin², Sue Pavitt³, Gavin Giovannoni⁴, Richard Parker⁵, Chris Weir⁵, Nigel Stallard⁶, Clive Hawkins⁷, Basil Sharrack⁸, Peter Connick⁹, Siddharthan Chandran⁹, Claudia Angela Gandini Wheeler-Kingshott ^1,10,11, Frederik Barkhof^2,12,13, and Jeremy Chataway¹

¹Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ²Translational Imaging Group (TIG), Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, ³Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom, ⁴Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom, ⁵Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom, ⁶Statistics and Epidemiology, Division of Health Sciences, Warwick Medical School, University of Warwick, Warwick, United Kingdom, ⁷Keele University Medical School, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom, ⁸Department of Neurology, Royal Hallamshire Hospital, Sheffield, United Kingdom, ⁹Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, ¹⁰Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ¹¹Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy, ¹²National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, United Kingdom, ¹³Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands

We investigated the cross-sectional relationships between thalamic lesions (i.e. total thalamic lesion volume), thalamic volume, and cognitive deficit in 55 subjects with secondary progressive multiple sclerosis. We measured: total intracranial volume, T2 lesion volume (T2LV), thalamic volume, thalamic lesions, and symbol digit modalities test (SDMT). Thalamic lesions inversely correlated with thalamic volume and these two variables were independently associated with cognitive deficit as measured by SDMT. After adjusting for T2LV, thalamic volume was the strongest predictor of cognitive deficit. Thalamic lesions may have clinical relevance independent of thalamic volume and will be longitudinally investigated in a bigger sample size.

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