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Abstract #0085

QSM identifies pro-inflammatory iron-positive MS lesions

Kelly Gillen1, Mayyan Mubarak2, Ishan Negi2, Somiah Dahlawi2, Thanh D Nguyen1, David Pitt2, and Yi Wang1

1Radiology, Weill Cornell Medical College, New York, NY, United States, 2Neurology, Yale University, New Haven, CT, United States

Multiple sclerosis is an autoimmune disorder whose demyelinated plaques may be connected with elevated iron. We combined quantitative susceptibility mapping (QSM) with histopathological techniques to quantify iron, macrophages/microglia, and pro/anti-inflammatory markers to demonstrate that regions of high susceptibility on QSM correspond to pro-inflammatory iron-positive macrophages/microglia. QSM is therefore a valuable clinical tool to identify smoldering lesions not visible using conventional MRI techniques.

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