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Abstract #0086

A longitudinal study of lesion evolution in Multiple Sclerosis using multi-contrast 7T MRI

Kingkarn Aphiwatthanasumet1, Olivier Mougin1, Nicolas Geades2, Nikos Evangelou3, Molly Bright3, Richard Bowtell1, and Penny Gowland1

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Philips Healthcare, Mölndal, Sweden, Mölndal, Sweden, 3Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom

We use multi-contrast 7T MRI to evaluate longitudinal changes in white matter tissue properties prior to and after lesion appearance. Four MS patients were scanned 6 times at 6-week intervals, and 20 new lesions were identified on FLAIR images in that period. Of these, 35% showed a hypointense rim and 65% showed no rim in QSM data. Subtle changes in MT, NOE, and QSM relative to NAWM values could be detected 6 weeks prior to the first clinical appearance of new lesions. In future studies, these data will provide insight into specific tissue changes that precede lesion development in MS.

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