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Abstract #0087

A 3-year follow-up study of enhancing and non-enhancing multiple sclerosis (MS) lesions in MS patients with clinically isolated syndrome (CIS) using a multi-compartment T2 relaxometry (MCT2) model

Sudhanya Chatterjee1, Olivier Commowick1, Onur Afacan2, Benoit Combès1, Anne Kerbrat1,3, Simon K Warfield2, and Christian Barillot1

1University of Rennes, INRIA, CNRS, INSERM, IRISA UMR 6074, VISAGES ERL U-1228, F-35000 Rennes, France, Rennes, France, 2CRL, Boston Children’s Hospital, Department of Radiology, 300 Longwood Avenue, WB215, Boston, MA 02115, USA, Boston, MA, United States, 3Department of Neurology, Rennes University Hospital, Rennes, France, Rennes, France

Obtaining information on condition of tissue microstructures (such as myelin, intra/extra cellular cells, free water) can provide important insights into MS lesions. However, MRI voxels are heterogeneous in terms of tissue microstructure due to the limited imaging resolution owing to existing physical limitations of MRI scanners. Here we evaluated a multi-compartment T2 relaxometry model and then used it to study the evolution of enhancing (USPIO and gadolinium positive) and non-enhancing lesions in 6 MS patients with CIS characteristics over a period 3 years with 7 follow-up scans after baseline.

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