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Abstract #0088

A multi-parametric study of MS lesions

Mara Cercignani1,2, Camilla Vizzotto1, Davide Esposito1, Barbara Spano2, Giovanni Giulietti2, and Marco Bozzali1,2

1Department of Neuroscience, Brighton & Sussex Medical School, Brighton, United Kingdom, 2Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy

Counter-intuitively, reduced orientation dispersion has been reported in MS lesions, and confirmed by histology. Here we classify lesional tissue based on its orientation dispersion, and we compute a series of indices from from diffusion and magnetization transfer MRI to highlight potential differences in the pathological substrate of lesions with reduced vs increased orientation dispersion. We show that lesions with reduced dispersion are more likely to show extensive demyelination and axonal loss.

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