Counter-intuitively, reduced orientation dispersion has been reported in MS lesions, and confirmed by histology. Here we classify lesional tissue based on its orientation dispersion, and we compute a series of indices from from diffusion and magnetization transfer MRI to highlight potential differences in the pathological substrate of lesions with reduced vs increased orientation dispersion. We show that lesions with reduced dispersion are more likely to show extensive demyelination and axonal loss.
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