Abstract #0089

The Age effect on Multi-parametric Magnetic Resonance Imaging changes in Multiple Sclerosis lesions

Elda Fischi-Gomez^1,2, Mário João Fartaria^2,3,4, Guillaume Bonnier¹, and Cristina Granziera^1,5

¹Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ²Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁵Neurology Department and Neuroimaging Laboratory, Basel University Hospital, Basel, Switzerland

We assessed the effect of age on the longitudinal evolution of intralesional neurite density and orientation dispersion indices, magnetization transfer ratio and T1 relaxometry in a cohort of relapsing-remitting MS patients. While we observed a decrease of neurite dispersion in lesions and stable neurite density, MTR and qT1, age did not seem to influence those longitudinal changes in MS lesions.

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