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Abstract #0096

CEST MRI ā€“ a potential tool for breast cancer grade and proliferation rate differentiation

Olgica Zaric1, Alex Farr2, Esau Poblador Rodriguez1, Vladimir Mlynarik1, Claudia Kronnerwetter1, Benjamin Schmitt3, Wolfgang Bogner1, Christian Singer2, and Siegfried Trattnig1

1High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria, 3Siemens Healthineers, Sydney, Australia

I this study, we investigated which CEST contrast changes are characteristic and dominant for breast malignancies. In 18 female patients, we performed DWI, CEST imaging, and T1-CE MRI. Significant differences in MTRasym between G1 and G3 was found (P= 0.007). Between G1 and G2 (P=0.066) as well as between G2 and G3 no difference were observed (P= 0.089). Correlation test demonstrated a strong positive correlation between mean MTRasym measured in region of its maximum and proliferation factor, Ki-67 (r=0.890, PĖ‚0.001). This preliminary results show that CEST-MRI of the breast has a potential to provide information regarding the tumor histological features.

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