Abstract #0097

ACRIN 6702 Multisite Breast DWI Trial: Comparison of Site vs. Centralized ADC Measures and Factors Affecting Data Quality

Savannah C Partridge¹, Zheng Zhang², Jennifer Whisenant³, Averi E Kitsch¹, Justin Romanoff², Habib Rahbar¹, Thomas Yankeelov⁴, and Thomas L Chenevert⁵

¹Radiology, University of Washington, Seattle, WA, United States, ²ACRIN Biostatistics Center, Brown University, Providence, RI, United States, ³Hematology/Oncology, Vanderbilt University, Nashville, TN, United States, ⁴Biomedical Engineering, University of Texas, Austin, TX, United States, ⁵Radiology, University of Michigan, Ann Arbor, MI, United States

Diffusion-weighted imaging (DWI) shows potential to improve lesion characterization and diagnostic performance of conventional contrast-enhanced breast MRI. Promising preliminary data from the ACRIN 6702 multisite trial show that DWI can reduce false-positive breast MRIs. Comparison of independently performed site and centrally-measured ADC values showed reasonable agreement, but suggest that further standardization of DWI interpretation and analysis tools across sites could improve diagnostic performance. Results also show more work is needed to address image quality issues and increase utility for measuring ADC values in MRI-detected breast lesions.

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