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Abstract #0099

Ultrafast Dynamic Contrast Enhanced MRI of the Breast Using DISCO: Are the Quantitative Parameters Helpful in Differentiating between BI-RADS 4 and 5 Subcentimeter Invasive Carcinomas and Benign Lesions?

Natsuko Onishi1, Meredith Sadinski1, Katherine M. Gallagher1,2, Brittany Z. Dashevsky1,3, Theodore M. Hunt1, Blanca Bernard-Davila1, Danny F. Martinez1, Amita Shukla-Dave1,4, Elizabeth A. Morris1, and Elizabeth J. Sutton1

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Lenox Hill Radiology, New York, NY, United States, 3Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 4Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States

The quantitative parameters derived from ultrafast dynamic contrast enhanced (UF-DCE) breast MRI using DISCO were analyzed for the assessment of possible utility in the differentiation between subcentimeter invasive carcinoma and benign lesions. Of all these parameters (MS, CER, IAUGC, BAT and Ktrans), BAT was the only parameter that predicted subcentimeter invasive carcinoma. We believe the significantly shorter BAT for subcentimeter invasive carcinomas is congruent with the known pathophysiology of cancer and may reflect its increased vascularity or shunt formation. BAT can be a complementary parameter to conventional steady-state DCE MRI, which could further stratify subcentimeter BI-RADS 4 and 5 lesions.

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