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Abstract #0100

Lymph node multi-parametric MRI characteristics of responders and non-responders of neoadjuvant chemotherapy

Renee F. Cattell1,2, James J. Kang1, Silu Han1,2, Thomas Ren1, Pauline B. Huang1, Haifang Li1, Jules A. Cohen3, Paul Fisher1, Roxanne Palermo1, and Tim Q. Duong1

1Department of Radiology, Stony Brook University, Stony Brook, NY, United States, 2Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 3Department of Medicine, Stony Brook University, Stony Brook, NY, United States

In the I-SPY 1 breast cancer clinical trial, change in size of the primary in-breast tumor in response to neoadjuvant therapy was a strong predictor of pathologic complete response. In this study, I-SPY 1 MRI lymph node characteristics was studied. Lymph nodes of patients who achieved pathologic complete response after chemotherapy had different characteristics from those who have residual disease in the tumor bed. The percent change of the signal enhancement ratio of each individual lymph node was the best parameter to differentiate between pathologic complete responders versus incomplete or non-responders.

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