Meeting Banner
Abstract #0103

Multimodal Assessment of Orbital Immune Cell Infiltration and Tissue Remodeling During Development of Graves’ Disease by 1H/19F MRI

Ulrich Flögel1, Anke Schlüter2, Christoph Jacoby1, Sebastian Temme1, J Paul Benga2, Anja Eckstein2, Jürgen Schrader1, and Utta Berchner-Pfannschmidt2

1Experimental Cardiovascular Imaging, Heinrich Heine University, Düsseldorf, Germany, 2University of Essen, Essen, Germany

The purpose of the present study was to evaluate key molecular and cellular features of Graves’ orbitopathy by simultaneous monitoring of alterations in morphology, inflammatory patterns, and tissue remodeling. Beyond anatomical 1H MRI, we employed T2 mapping for visualization of edema, chemical exchange saturation transfer for detection of hyaluronan, and 19F MRI for tracking of in situ labeled immune cells after intravenous injection of perfluorcarbons. In particular, 19F MRI allowed a sensitive demarcation of inflammatory foci in the orbit, even when other markers indicated only weak or no signs of tissue alterations.

This abstract and the presentation materials are available to members only; a login is required.

Join Here