Abstract #0103

Multimodal Assessment of Orbital Immune Cell Infiltration and Tissue Remodeling During Development of Graves’ Disease by 1H/19F MRI

Ulrich Flögel¹, Anke Schlüter², Christoph Jacoby¹, Sebastian Temme¹, J Paul Benga², Anja Eckstein², Jürgen Schrader¹, and Utta Berchner-Pfannschmidt²

¹Experimental Cardiovascular Imaging, Heinrich Heine University, Düsseldorf, Germany, ²University of Essen, Essen, Germany

The purpose of the present study was to evaluate key molecular and cellular features of Graves’ orbitopathy by simultaneous monitoring of alterations in morphology, inflammatory patterns, and tissue remodeling. Beyond anatomical ¹H MRI, we employed T2 mapping for visualization of edema, chemical exchange saturation transfer for detection of hyaluronan, and ¹⁹F MRI for tracking of in situ labeled immune cells after intravenous injection of perfluorcarbons. In particular, ¹⁹F MRI allowed a sensitive demarcation of inflammatory foci in the orbit, even when other markers indicated only weak or no signs of tissue alterations.

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