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Abstract #0104

Hyperpolarized Xe-129 Imaging of Pluripotent Stem Cell-Derived Alveolar-Like Macrophages in the Lungs: Proof-of-Concept Study Using Superparamagnetic Iron-Oxide Nanoparticles

Vlora Riberdy1,2, Michael Litvack2, Elaine Stirrat2, Marcus Couch2, Martin Post2, and Giles Santyr1,2

1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada

A promising approach to treatment of chronic lung diseases is the intratracheal delivery of pluripotent stem cell derived alveolar-like macrophages (PSC-ALMs) into the injured lung to facilitate repair of damaged tissue. This treatment is hindered by the inability to assess where in the lung these cells end up. Here, hyperpolarized Xe-129 MRI paired with iron-labeled cells was used to demonstrate a proof-of-concept visualization of cells introduced in the lungs of rats. Signal hypointensities were observed at least one hour after instillation of approximately two million labeled cells in one rat, compared to instillation of control solutions in separate rats.

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