Silicon nano- and microparticles are well-suited for targeted molecular imaging, due to their biocompatibility, easily modifiable surface, and long-lasting 29Si MR signal (which can be enhanced by several orders of magnitude via dynamic nuclear polarization). We demonstrate targeted molecular imaging of human MUC1-expressing colon tumors in orthotopic mouse models using hyperpolarized 29Si MRI. The particles were able to selectively bind to MUC1-expressing tumors compared to controls, and the results were confirmed via histology of the excised tissue. The goal is to develop these targeted particles as a platform technology that will allow non-invasive screening of colorectal cancer using 29Si MRI.
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