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Abstract #0105

In Vivo Molecular Imaging of MUC1-Expressing Colorectal Tumors Using Targeted Hyperpolarized Silicon Particles

Nicholas Whiting1,2, Jingzhe Hu1,3, Shivanand Pudakalakatti1, Caitlin McCowan1,3, Daniel Carson3, Jennifer Davis1, Niki Millward1, David Menter1, Pamela Constantinou3, and Pratip Bhattacharya1

1The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Rowan University, Glassboro, NJ, United States, 3Rice University, Houston, TX, United States

Silicon nano- and microparticles are well-suited for targeted molecular imaging, due to their biocompatibility, easily modifiable surface, and long-lasting 29Si MR signal (which can be enhanced by several orders of magnitude via dynamic nuclear polarization). We demonstrate targeted molecular imaging of human MUC1-expressing colon tumors in orthotopic mouse models using hyperpolarized 29Si MRI. The particles were able to selectively bind to MUC1-expressing tumors compared to controls, and the results were confirmed via histology of the excised tissue. The goal is to develop these targeted particles as a platform technology that will allow non-invasive screening of colorectal cancer using 29Si MRI.

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