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Abstract #0106

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes

Hecong Qin1,2, Valerie Carroll1, Renuka Sriram1, Cornelius von Morze1, Zhen Jane Wang1, Christopher Mutch1, Kayvan R. Keshari3, Robert R. Flavell1, John Kurhanewciz1,2, and David M. Wilson1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, CA, United States, 3Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

We studied brain redox capacity using ascorbate-derived hyperpolarized (HP) 13C MR and 11C PET probes. We first demonstrated the molecular transport and biodistribution features of the ascorbic acid (VitC)-dehydroascorbate (DHA) pair by leveraging both HP MR and PET modalities. We then showed that HP 13C DHA could detect redox modulation of the brain in a pharmacologic glutathione-depletion rat model. In conclusion, HP 13C DHA MR has the potential for non-invasive evaluation of brain redox capacity.

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