Abstract #0106

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes

Hecong Qin^1,2, Valerie Carroll¹, Renuka Sriram¹, Cornelius von Morze¹, Zhen Jane Wang¹, Christopher Mutch¹, Kayvan R. Keshari³, Robert R. Flavell¹, John Kurhanewciz^1,2, and David M. Wilson¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, CA, United States, ³Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

We studied brain redox capacity using ascorbate-derived hyperpolarized (HP) ¹³C MR and ¹¹C PET probes. We first demonstrated the molecular transport and biodistribution features of the ascorbic acid (VitC)-dehydroascorbate (DHA) pair by leveraging both HP MR and PET modalities. We then showed that HP ¹³C DHA could detect redox modulation of the brain in a pharmacologic glutathione-depletion rat model. In conclusion, HP ¹³C DHA MR has the potential for non-invasive evaluation of brain redox capacity.

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