Abstract #0109

Hollow Manganese-Silicate (HMS) Nanoparticles as a Liver Specific MRI contrast agent

Moon-Sun Jang¹, Jin Goo Kim², Geun Ho Im¹, Jung Hee Lee^1,3, Won Jae Lee¹, and In Su Lee²

¹Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ²National Creative Research Initiative Center for Nanospace-confined Chemical Reactions and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Gyeongbuk, Republic of Korea, ³Departments of Health Science and Technology and Medical Device Management and Research, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea

In this study, we demonstrate hollow manganese silicate nanoparticle (HMS) as a liver specific magnetic resonance imaging (MRI) contrast agent. HMS releases Mn²⁺ ions in the acidic physiological condition, which can be utilized for characterizing different tumor types.

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