Abstract #0110

Magnetic Resonance Temperature Imaging for Nanoparticle-Mediated Tumor Photothermal Therapy

Fu Guifeng^1,2, Guo Jianxin¹, Wei Xiaocheng³, Zhang Fan², and Yang Jian¹

¹Medical Imaging Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, ²Center for Molecular Imaging and Translational Medicine, Xiamen University, Xiamen, China, ³MR Research China, GE Healthcare, Beijing, China

Image-guided cancer therapy have the ability to integrate noninvasive imaging and minimally invasive interventions such as photothermal therapy (PTT) together to improve the precision of treatment. In the present study, we investigated magnetic resonance temperature imaging (MRTI) as a tool for non-invasive monitoring of tumor temperature distribution and changes during laser irradiation. To this end, we injected PEGylated graphene oxide (GO-PEG) to 4T1 tumor models and irradiated the tumors to induce PTT. Our studies demonstrate that MRTI, which is a feasible tool for the determination of temperature distribution, can be used to guide nanoparticle-mediated tumor photothermal therapy.

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