The pH-value as physiological marker for clinical diagnosis can be measured with special hardware over 31P-MRSI. APT-CEST MRI offers an alternative method for such quantification but is challenging because of magnetization transfer from other tissue compartments.
To evaluate the role of pH for APT-CEST, we investigated 12 patients with first diagnosis of glioblastoma and 11 healthy controls, based on asymmetric analysis of magnetization transfer (MTRasym) and calculated pH maps over 31P-MRSI.
Our results show a high correlation between both parameters and support the hypothesis that an enhancement of MTRasym at 3.5ppm is associated with increased pH.How to access this content:
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