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Abstract #0114

Correlation of tissue pH via 31P-MRSI with MTRasym derived from APT-CEST-MRI in glioblastoma and normal appearing white matter

Jan Rüdiger Schüre1, Stella Breuer1, Manoj Shrestha2, Ralf Deichmann2, Marlies Wagner1, and Ulrich Pilatus1

1Neuroradiology, University Hospital Frankfurt, Frankfurt am Main, Germany, 2Brain Imaging Center, Goethe University Frankfurt, Frankfurt am Main, Germany

The pH-value as physiological marker for clinical diagnosis can be measured with special hardware over 31P-MRSI. APT-CEST MRI offers an alternative method for such quantification but is challenging because of magnetization transfer from other tissue compartments.

To evaluate the role of pH for APT-CEST, we investigated 12 patients with first diagnosis of glioblastoma and 11 healthy controls, based on asymmetric analysis of magnetization transfer (MTRasym) and calculated pH maps over 31P-MRSI.

Our results show a high correlation between both parameters and support the hypothesis that an enhancement of MTRasym at 3.5ppm is associated with increased pH.

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