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Abstract #0115

Imaging vascular inflammation as a marker for T-cell infiltration in preclinical tumor models.

Johannes Riegler1, Vincent Javinal2, Maj Hedehus1, Jill Schartner2, and Richard A.D. Carano1

1Biomedical Imaging, Genentech, South San Francisco, CA, United States, 2Genentech, South San Francisco, CA, United States

Checkpoint inhibitors, adoptive T-cell transfer and tumor vaccination are different cancer immunotherapies which have demonstrated clinical efficacy in certain patients1-3. All of these therapies require sufficient infiltration of cytotoxic T-cells into the tumor and direct contact with cancer cells. However, the reasons why certain tumors present with high T-cell infiltration while others do not are poorly understood. We therefore set out to assess if imaging vascular adhesion molecule 1 (VCAM-1) expression in the tumor vasculature could explain some of the observed differences in T-cell infiltration.

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