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Abstract #0122

Evaluating intratumoral necrosis in gliomas: a multi-modal study of acidosis, cellularity, and vascularity

Maxime Parent1, John J. Walsh2, Lucas C. Adam1, Daniel Coman1, and D.S. Fahmeed Hyder1,2

1Radiology & Biomedical Imaging, Yale University, New Haven, CT, United States, 2Biomedical Engineering, Yale University, New Haven, CT, United States

The malignant form of human glioblastoma multiforme (GBM) is linked to intratumoral necrosis. Since novel immunotherapies are being sought to treat these patients, non-invasively characterizing intratumoral necrosis in gliomas is clinically important. Here, we describe a multi-modal MRI study of acidity, cellularity, and vascularity in two glioma models that feature comparable necrosis and proliferation, but differ in vascular markers. The intratumoral necrotic core (INC) and intratumoral surrounding tissue (IST) had distinct slow and fast Gd-enhanced profiles, respectively. Despite immunohistochemical/histopathological differences, these GBM models show similar profiles of INC-IST gradients for acidity and cellularity, but not for vascularity.

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