Abstract #0123

Oxygen enhanced-MRI detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients

Ahmed Salem^1,2, Ross Little³, Adam Featherstone³, Muhammad Babur⁴, Hitesh Mistry⁴, Susan Cheung³, Yvonne Watson³, Victoria Tessyman⁴, Marie-Claude Asselin³, Alan Jackson³, Kaye Williams⁴, Geoffrey Parker^3,5, Corinne Faivre-Finn^1,2, and James O'Connor^1,6

¹Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, ²Department of Clinical Oncology, The Christie Hospital NHS Trust, Manchester, United Kingdom, ³Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom, ⁴Division of Pharmacy and Optometry, University of Manchester, Manchester, United Kingdom, ⁵Bioxydyn Ltd, Manchester, United Kingdom, ⁶Department of Radiology, The Christie Hospital NHS Trust, Manchester, United Kingdom

Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here, we report a world first-in-man study showing that OE-MRI signals in perfused tumour can non-invasively track changes in hypoxia induced by radiotherapy. We show that OE-MRI detects (1) reduction in hypoxia in Calu6 xenografts and that this change is due to hypoxia modification; and (2) reduction in hypoxia is also seen in 14 patients with non-small cell lung cancer. These data support first-in-man use of OE-MRI biomarkers in clinical trials of (chemo)-radiotherapy as single agent or in combination with hypoxia-modifying agents.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.