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Abstract #0124

Assessment of Distant Tumor Stimulation from Liver Radiofrequency Ablation in a Rat Breast Carcinoma Model using Hyperpolarized 13C-Pyruvate MRI

Joseph Scott Goodwin1, David Mwin1, Patricia Coutinho de Souza1, Svayam Dialani1, John T Moon1, Aaron K Grant1, Muneeb Ahmed1, and Leo L Tsai1

1Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States

Radiofrequency ablation (RFA) is commonly used to treat tumors such as hepatocellular carcinomas. However, there is evidence that liver RFA can stimulate growth in tumors at other sites, a process attributed to the HFG/c-Met pathway. Hyperpolarized 13C-pyruvate MRI showed increased intratumoral lactate production in subcutaneously-implanted R3230 tumors following RFA of normal liver in a rat model. This effect is suppressed when liver RFA is combined with a c-Met inhibitor. 13C MRI could potentially be used to identify tumors at risk for this off-target effect.

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