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Abstract #0128

In vivo cancer detection and dynamics with magnetic particle imaging

Elaine Yu1, Mindy Bishop1, Bo Zheng1, R Matthew Ferguson2, Amit P Khandhar2, Scott J Kemp2, Kannan M Krishnan2,3, Patrick Goodwill1,4, and Steven Conolly1,5

1Department of Bioengineering, University of California, Berkeley, CA, United States, 2Lodespin Labs, Seattle, WA, United States, 3Department of Material Science and Engineering, University of Washington, Seattle, WA, United States, 4Magnetic Insight, Inc., Alameda, CA, United States, 5Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States

Magnetic Particle Imaging (MPI) is a novel, high-contrast, and quantitative imaging modality that directly detects superparamagnetic iron oxide nanoparticle (SPIO) tracers. These SPIOs have been previously used as a MRI contrast agent. However, with MRI SPIOs are limited by poor specificity and difficulty associated with quantifying the negative signal. MPI enables the direct detection of these SPIOs with both high sensitivity and positive contrast. MPI is well poised to support MRI in developing a clinically translatable cancer detection platform with SPIO. Here we demonstrate in vivo cancer detection and dynamic perfusion imaging with MPI.

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