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Abstract #0127

Two Dimensional COSY on Biopsy Distinguishes Indolent From Aggressive Kidney Masses

Aaron Urquhart1, Sharon Del Vecchio2, Lutz Krause3, Robert Ellis2, Keng Lim Ng4, Hema Samaratunga5, Sonja Gustafson6, Graham Galloway1,3, Glenda Gobe2, Peter Malycha1, Simon Wood4, and Carolyn Mountford1

1Translational Research Institute, Brisbane, Australia, 2Faculty of Medicine, The University of Queensland, Brisbane, Australia, 3The University of Queensland, Brisbane, Australia, 4Department of Urology, Princess Alexandra Hospital, Brisbane, Australia, 5Aquesta Uropathology, Brisbane, Australia, 6Department of Radiology, Princess Alexandra Hospital, Brisbane, Australia

Kidney tumour metabolism may have chemical signatures that distinguish indolent from aggressive small renal masses (SRM). Indolent or benign SRM could be managed conservatively. Here we have used two dimensional (2D) COrrelation SpectroscopY (COSY) on nephrectomy samples to assign and measure metabolite and lipid resonances. High level bioinformatics analysis was then applied. We report metabolic chemical signatures that can be used to distinguish histologically-diagnosed kidney tumour subtypes.

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