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Abstract #0126

Human Hyperpolarized 13C MR of Liver and Bone Metastases using both EPSI and EPI Acquisitions

Zihan Zhu1,2, Jeremy W Gordon1, Hsin-Yu Chen1, Eugene Milshteyn1,2, Daniele Mammoli1, Lucas Carvajal1, Peter J Shin1, Rahul Aggarwal3, Robert Bok1, John Kurhanewicz1, Pamela Munster3, and Daniel B Vigneron1

1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley - UCSF Graduate Program in Bioengineering, UCSF, San Francisco, CA, United States, 3Department of Medicine, UCSF, San Francisco, CA, United States

Hyperpolarized 13C metabolic imaging is a powerful technique with proven safety and efficacy for human studies. The goal of this project was to investigate pyruvate metabolism in patients with prostate and breast cancer metastases with both echo-planar spectroscopic imaging (EPSI) and the echo-planar imaging (EPI) acquisitions in the same exam. The results revealed similarly valuable information of up-regulated LDH-catalyzed conversion of pyruvate to lactate with some advantages and differences between the two acquisition methods.

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