Whole-body MRI (WB-MRI) offers an alternative non-ionising radiation technique to current gold-standard imaging, 18F-FDG PET-CT, for assessment of paediatric and adolescent Hodgkin's lymphoma (HL).
In this work we prospectively evaluated WB-MRI, including diffusion-weighted-imaging (DWI), for initial staging and early interim response monitoring in 50 paediatric HL patients.
WB-MRI with DWI has reasonable intrinsic diagnostic accuracy for nodal and extra-nodal staging of paediatric HL but it fails to achieve full concordance with standard imaging for all disease sites in minority of patients.
WB-MRI has reasonable accuracy for interim response classification but tends to underestimate disease response, particularly in extra-nodal disease sites.
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