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Abstract #0131

Whole body functional and anatomical MRI: Accuracy in staging and interim response monitoring of Childhood and Adolescent Hodgkin’s Lymphoma compared to multimodality conventional imaging

Arash Latifoltojar1, Shonit Punwani1, Andre Lopes2, Paul D Humphries1, Deena Neriman3, Leon Menezes3, Stephen Daw4, Ananth Shankar4, Bilyana Popova2, K M Mak2, Heather Fitzke1, Paul Smith2, Laura Clifton-Hadley2, and Stuart Andrew Taylor1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Cancer Research UK and UCL Cancer Trial Centre, University College London, London, United Kingdom, 3Institute of Nuclear Medicine, University College London Hospital, London, United Kingdom, 4Department of Paediatric Haemato-oncology, University College London Hospital, London, United Kingdom

Whole-body MRI (WB-MRI) offers an alternative non-ionising radiation technique to current gold-standard imaging, 18F-FDG PET-CT, for assessment of paediatric and adolescent Hodgkin's lymphoma (HL).

In this work we prospectively evaluated WB-MRI, including diffusion-weighted-imaging (DWI), for initial staging and early interim response monitoring in 50 paediatric HL patients.

WB-MRI with DWI has reasonable intrinsic diagnostic accuracy for nodal and extra-nodal staging of paediatric HL but it fails to achieve full concordance with standard imaging for all disease sites in minority of patients.

WB-MRI has reasonable accuracy for interim response classification but tends to underestimate disease response, particularly in extra-nodal disease sites.

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