Abstract #0131

Whole body functional and anatomical MRI: Accuracy in staging and interim response monitoring of Childhood and Adolescent Hodgkin’s Lymphoma compared to multimodality conventional imaging

Arash Latifoltojar¹, Shonit Punwani¹, Andre Lopes², Paul D Humphries¹, Deena Neriman³, Leon Menezes³, Stephen Daw⁴, Ananth Shankar⁴, Bilyana Popova², K M Mak², Heather Fitzke¹, Paul Smith², Laura Clifton-Hadley², and Stuart Andrew Taylor¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Cancer Research UK and UCL Cancer Trial Centre, University College London, London, United Kingdom, ³Institute of Nuclear Medicine, University College London Hospital, London, United Kingdom, ⁴Department of Paediatric Haemato-oncology, University College London Hospital, London, United Kingdom

Whole-body MRI (WB-MRI) offers an alternative non-ionising radiation technique to current gold-standard imaging, 18F-FDG PET-CT, for assessment of paediatric and adolescent Hodgkin's lymphoma (HL).

In this work we prospectively evaluated WB-MRI, including diffusion-weighted-imaging (DWI), for initial staging and early interim response monitoring in 50 paediatric HL patients.

WB-MRI with DWI has reasonable intrinsic diagnostic accuracy for nodal and extra-nodal staging of paediatric HL but it fails to achieve full concordance with standard imaging for all disease sites in minority of patients.

WB-MRI has reasonable accuracy for interim response classification but tends to underestimate disease response, particularly in extra-nodal disease sites.

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