Following traumatic brain injury (TBI), numerous microscale cellular alterations appear and evolve with a range of consequences for adverse outcomes and recovery. Diffusion tensor MRI (DTI) has been identified as a potentially sensitive tool for characterizing these changes, but is notably limited in providing specific information about particular cellular alterations and more advanced non-Gaussian frameworks have been developed that may address these limitations. To assess the utility of non-Gaussian modeling for improved detection and specification of TBI-related cellular alterations, we compared DTI, DKI and MAP-MRI in mouse brains following mild TBI and their correspondence to histopathology in the same tissue.
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