Abstract #0133

Histological Validation of in-vivo VERDICT MRI for Prostate using 3D Personalised Moulds

Elisenda Bonet-Carne^1,2, Maira Tariq¹, Hayley Pye³, Mrishta Brizmohun Appayya², Aiman Haider⁴, Colleen Bayley¹, Joseph Jacobs¹, Alexander Freeman⁴, David Hawkes¹, David Atkinson², Greg Shaw⁵, Hayley Whitaker³, Daniel C Alexander¹, Shonit Punwani², and Eleftheria Panagiotaki¹

¹Centre for Medical Image Computing, University College London, London, United Kingdom, ²Centre for Medical Imaging, University College London, London, United Kingdom, ³Research Department for Tissue & Energy, University College London, London, United Kingdom, ⁴Department of Pathology, University College London Hospital, London, United Kingdom, ⁵Division of Surgery and Interventional Science, University College London, London, United Kingdom

VERDICT analysis can successfully distinguish benign from malignant prostate tissue in-vivo showing promising results as a cancer diagnostic tool. However, the accuracy with which model parameters reflect the underlying tissue characteristics is unknown. In this study, we quantitatively compare the intracellular, extracellular-extravascular and vascular volume fractions derived from in-vivo VERDICT MRI against histological measurements from prostatectomies. We use 3D-printed personalised moulds designed from in-vivo MRI that help preserve the orientation and location of the gland and aid histological alignment. Results from the first samples using the 3D mould pipeline show good agreement between in-vivo VERDICT estimates and histology.

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