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Abstract #0133

Histological Validation of in-vivo VERDICT MRI for Prostate using 3D Personalised Moulds

Elisenda Bonet-Carne1,2, Maira Tariq1, Hayley Pye3, Mrishta Brizmohun Appayya2, Aiman Haider4, Colleen Bayley1, Joseph Jacobs1, Alexander Freeman4, David Hawkes1, David Atkinson2, Greg Shaw5, Hayley Whitaker3, Daniel C Alexander1, Shonit Punwani2, and Eleftheria Panagiotaki1

1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Centre for Medical Imaging, University College London, London, United Kingdom, 3Research Department for Tissue & Energy, University College London, London, United Kingdom, 4Department of Pathology, University College London Hospital, London, United Kingdom, 5Division of Surgery and Interventional Science, University College London, London, United Kingdom

VERDICT analysis can successfully distinguish benign from malignant prostate tissue in-vivo showing promising results as a cancer diagnostic tool. However, the accuracy with which model parameters reflect the underlying tissue characteristics is unknown. In this study, we quantitatively compare the intracellular, extracellular-extravascular and vascular volume fractions derived from in-vivo VERDICT MRI against histological measurements from prostatectomies. We use 3D-printed personalised moulds designed from in-vivo MRI that help preserve the orientation and location of the gland and aid histological alignment. Results from the first samples using the 3D mould pipeline show good agreement between in-vivo VERDICT estimates and histology.

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