In this work we have developed a novel functional MRE system for humans capable of probing stiffness changes in the brain driven by monocular visual stimulation. A continuous visual stimulus was applied at an ON/OFF frequency of 1.35 Hz during a segmented 2D multi-slice MRE sequence with 3D motion encoding operating at 50 Hz vibration frequency. Significant stiffness changes were recorded between ON/OFF during the stimulus experiment that also differed in baseline to control scans (OFF/OFF). Since the BOLD signal is entirely saturated at such high stimulation frequencies, we hypothesize that stiffness changes are due to direct neuronal activities. Data match similar results obtained in mice.
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